• Νέα δημοσίευση από τον Μανόλη Καλαμπόκα και την Κλινική Γυναικολογικής Ογκολογίας του Πανεπιστημίου του Aberdeen στο παγκόσμιο περιοδικό της Αμερικανικής Ένωσης Κολποσκόπησης και Παθολογίας Τραχήλου

    28279204_1580971501968295_3285796868707161984_n

    
    
    
    
    J Low Genit Tract Dis. 2018 Feb 23. doi: 10.1097/LGT.0000000000000373. [Epub
    ahead of print]
    
    Effect of High-Risk Human Papillomavirus but Normal Cytology at Test of Cure on
    Achieving Colposcopy Standards.
    
    Kalampokas E(1), Wilson J, Gurumurthy M, Cruickshank ME.
    
    Author information: 
    (1)Department of Gynaecologic Oncology, Aberdeen Royal Infirmary, Aberdeen,
    United Kingdom.
    
    OBJECTIVE: In United Kingdom., test of cure after treatment of any grade of
    cervical intraepithelial neoplasia (CIN) incorporates high-risk human
    papillomavirus (Hr-HPV) test and cytology at 6-month follow-up. The aims of the
    study were to determine the rate of recurrent CIN in women who are Hr-HPV
    positive and cytology negative and to explore possible associated risk factors.
    METHODS: A retrospective observational cohort study was performed in women
    treated for any grade CIN between 2010 and 2015 from a regional population, who
    were Hr-HPV positive and cytology negative at first follow-up.
    RESULTS: A total of 2729 women were identified as treated for any grade CIN, and 
    213 (7.8%) were re-referred to colposcopy having Hr-HPV-positive test and
    negative cytology at test of cure. Their mean age was 31.56 years (range = 19-62 
    years). The mean time of follow-up per woman was 30.50 months (range = 2-63
    months). At colposcopy, 171 (80.3%) had colposcopy examination only and 42 women 
    (19.7%) had a biopsy. Twenty-four cases (11.3%) of CIN were identified of which 4
    (1.9%) were CIN 2/3. Eleven women (5.2%) in total had a repeat treatment. Five
    women (2.3%) had biopsy-proven CIN 2/3 within 12-months after treatment. No cases
    of CIN 3+ after negative colposcopy were identified during the follow-up period.
    CONCLUSIONS: The incorporation of Hr-HPV testing yielded a very small number of
    women with residual CIN within 12 months of treatment. Our results suggest that
    women who are Hr-HPV positive and cytology negative after treatment of CIN with
    normal and adequate colposcopy could be discharged to routine recall if confirmed
    by larger national data.